Over 70 percent of the body’s immune cells are located in the gut. Acemannan must be the correct size to be detected and engulfed by macrophages. Macrophages, essential immune cells, act as directors of various immune responses. Studies have shown that Acemannans with a molecular weight of < 400 kDa are powerful macrophage activators while those larger than 400 kDa have only a marginal immunomodulatory activity. Activated macrophages are deeply involved in self-regulated immunomodulation.
Acemannans with a molecular weight of less than 50 kDa can be absorbed immediately through the intestinal walls and transported into the blood stream. The role of mannose is so important to our overall health and immune function that epithelial cells lining the gut have mannose-specific receptors for the active uptake of these manose structures from our diets. Once absorbed, they are transported directly in to the blood stream and delivered to other cells, tissues, and organs throughout the body. Mannose is essential for all cellular functions,
including those involved in repair, regeneration, and defense.
Immune Support combines the best standards of care with the best technology to achieve best patient outcomes.
*Materials and MethodsSamplesImmune Support, C, P, and A were ranked based upon their respective Total Acemannan. Numerous “other” samples were tested; however, they did not qualify for inclusion in the graph because they lack the full range of immunomodulatory Acemannan. For each sample listed, the Total acemannan was calculated using the “o-acetyl method” then checked against the SEC (Size Exclusion Chromatography) for accuracy using the total polysaccharides as the marker. The SEC data was also used to determine the < 50 kDa and < 400 kDa Fractions. Both tests were performed by different independant laboratories using blind samples.